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Issue 3, 2007
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Recent approaches towards the asymmetric synthesis of α,α-disubstituted α-amino acids

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Abstract

The class of α,α-disubstituted α-amino acids has gained considerable attention in the past decades and continues doing so. The ongoing interest in biological and chemical properties of the substance class has inspired the development of many new methodologies for their asymmetric construction, which have not found their way into the general focus of organic chemistry yet. The aim of this review is to provide an overview of the developments in the field since 1998.

Graphical abstract: Recent approaches towards the asymmetric synthesis of α,α-disubstituted α-amino acids

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Publication details

The article was received on 01 Aug 2006, accepted on 10 Nov 2006 and first published on 30 Nov 2006


Article type: Perspective
DOI: 10.1039/B611091F
Org. Biomol. Chem., 2007,5, 406-430

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    Recent approaches towards the asymmetric synthesis of α,α-disubstituted α-amino acids

    H. Vogt and S. Bräse, Org. Biomol. Chem., 2007, 5, 406
    DOI: 10.1039/B611091F

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