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Issue 4, 2007
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Microcins, gene-encoded antibacterial peptides from enterobacteria

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Abstract

Covering 1982 to 2006

Microcins are gene-encoded antibacterial peptides, with molecular masses below 10 kDa, produced by enterobacteria. They are secreted under conditions of nutrient depletion and exert potent antibacterial activity against closely related species. Typical gene clusters encoding the microcin precursor, the self-immunity factor, the secretionproteins and frequently the post-translational modification enzymes are located either on plasmids or on the chromosome. In contrast to most of the antibiotics of microbial origin, which are non-ribosomally synthesized by multimodular enzymes termed peptide synthetases, microcins are ribosomally synthesized as precursors, which are further modified enzymatically. They form a restricted class of potent antibacterial peptides. Fourteen microcins have been reported so far, among which only seven have been isolated and characterized. Despite the low number of known representatives, microcins exhibit a diversity of structures and antibacterial mechanisms. This review provides an updated overview of microcin structures, antibacterial activities, genetic systems and biosyntheses, as well as of their mechanisms of action.

Graphical abstract: Microcins, gene-encoded antibacterial peptides from enterobacteria

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Publication details

The article was received on 05 Dec 2006 and first published on 18 Apr 2007


Article type: Review Article
DOI: 10.1039/B516237H
Nat. Prod. Rep., 2007,24, 708-734

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    Microcins, gene-encoded antibacterial peptides from enterobacteria

    S. Duquesne, D. Destoumieux-Garzón, J. Peduzzi and S. Rebuffat, Nat. Prod. Rep., 2007, 24, 708
    DOI: 10.1039/B516237H

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