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Issue 10, 2007
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Tailoring tripodal ligands for zinc sensing

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Zinc plays an important role in biological processes. It is implicated in many diseases, including those affecting the brain. Imaging zinc is becoming crucial to the elucidation of zinc concentration, distribution, kinetics and functions in cells and tissues. This review highlights recent advances in the development of picolylamine-based tripodal compounds as zinc sensors, especially our work in the field of sensing “invisible” Zn(II) using steady-state fluorescence, fluorescence lifetimes and chiroptical spectroscopy. Our approach has emphasized creative ligand design and detection schemes. Utilizing tris(2-pyridylmethyl)amine-based N4 tripodal ligands has provided a flexible system for engineering zinc sensors with improved sensitivity, selectivity and contrast. Also included are results with tripodal ligands that have focused more on applications.

Graphical abstract: Tailoring tripodal ligands for zinc sensing

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Publication details

The article was received on 17 Jul 2007, accepted on 28 Aug 2007 and first published on 11 Sep 2007

Article type: Perspective
DOI: 10.1039/B710803F
New J. Chem., 2007,31, 1708-1718

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    Tailoring tripodal ligands for zinc sensing

    Z. Dai and J. W. Canary, New J. Chem., 2007, 31, 1708
    DOI: 10.1039/B710803F

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