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Issue 10, 2007
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Tailoring tripodal ligands for zinc sensing

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Abstract

Zinc plays an important role in biological processes. It is implicated in many diseases, including those affecting the brain. Imaging zinc is becoming crucial to the elucidation of zinc concentration, distribution, kinetics and functions in cells and tissues. This review highlights recent advances in the development of picolylamine-based tripodal compounds as zinc sensors, especially our work in the field of sensing “invisible” Zn(II) using steady-state fluorescence, fluorescence lifetimes and chiroptical spectroscopy. Our approach has emphasized creative ligand design and detection schemes. Utilizing tris(2-pyridylmethyl)amine-based N4 tripodal ligands has provided a flexible system for engineering zinc sensors with improved sensitivity, selectivity and contrast. Also included are results with tripodal ligands that have focused more on applications.

Graphical abstract: Tailoring tripodal ligands for zinc sensing

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Article information


Submitted
17 Jul 2007
Accepted
28 Aug 2007
First published
11 Sep 2007

New J. Chem., 2007,31, 1708-1718
Article type
Perspective

Tailoring tripodal ligands for zinc sensing

Z. Dai and J. W. Canary, New J. Chem., 2007, 31, 1708
DOI: 10.1039/B710803F

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