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Issue 11, 2007
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Nanostructured assemblies from nucleotide-based amphiphiles

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A synthetic route to 3′-O-alkyl nucleotides is described that provides easy access to a series of nucleotide-based amphiphiles. Physicochemical experiments demonstrate that these nucleotide amphiphiles possess different aggregating properties compared to both their non-nucleotide analogues and simple nucleotides. The data collected from TEM, SEM, FT-IR and WAXS studies indicate that the aqueous dispersion of these nucleotide amphiphiles provides nanostructured assemblies such as ribbon-like structures for the thymidine derivatives and small aggregates for adenine. These results indicate that the nature of the base has an impact on aggregate morphology. A molecular model illustrating the 3D supramolecular arrangements of a thymidine nucleoamphiphile forming ribbons is proposed.

Graphical abstract: Nanostructured assemblies from nucleotide-based amphiphiles

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Publication details

The article was received on 02 Apr 2007, accepted on 04 Jul 2007 and first published on 06 Aug 2007

Article type: Paper
DOI: 10.1039/B704884J
New J. Chem., 2007,31, 1928-1934

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    Nanostructured assemblies from nucleotide-based amphiphiles

    N. Campins, P. Dieudonné, M. W. Grinstaff and P. Barthélémy, New J. Chem., 2007, 31, 1928
    DOI: 10.1039/B704884J

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