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Issue 9, 2007
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Design and fabrication of chemically robust three-dimensional microfluidic valves

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Abstract

A current problem in microfluidics is that poly(dimethylsiloxane) (PDMS), used to fabricate many microfluidic devices, is not compatible with most organic solvents. Fluorinated compounds are more chemically robust than PDMS but, historically, it has been nearly impossible to construct valves out of them by multilayer soft lithography (MSL) due to the difficulty of bonding layers made of “non-stick” fluoropolymers necessary to create traditional microfluidic valves. With our new three-dimensional (3D) valve design we can fabricate microfluidic devices from fluorinated compounds in a single monolithic layer that is resistant to most organic solvents with minimal swelling. This paper describes the design and development of 3D microfluidic valves by molding of a perfluoropolyether, termed Sifel, onto printed wax molds. The fabrication of Sifel-based microfluidic devices using this technique has great potential in chemical synthesis and analysis.

Graphical abstract: Design and fabrication of chemically robust three-dimensional microfluidic valves

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Submitted
03 Apr 2007
Accepted
18 Jun 2007
First published
09 Jul 2007

Lab Chip, 2007,7, 1209-1211
Article type
Technical Note

Design and fabrication of chemically robust three-dimensional microfluidic valves

G. Maltezos, E. Garcia, G. Hanrahan, F. A. Gomez, S. Vyawhare, R. M. van Dam, Y. Chen and A. Scherer, Lab Chip, 2007, 7, 1209
DOI: 10.1039/B705031C

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