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Issue 38, 2007
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Hydrogel-coated and platinum coils for intracranial aneurysm embolization compared in three experimental models using computerized angiographic and histologic morphometry

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Abstract

Angiographic and histologic results of hydrogel-coated (HydroCoil®) and platinum coil-treated canine sidewall, canine bifurcation, and rabbit elastase aneurysms (2–52 weeks follow-ups) were quantified by computer-assisted morphometry. Angiograms were analyzed using density determination to differentiate embolic mass and contrast medium filling. Aneurysm total and occluded areas, embolic material and red thrombus areas were determined from images of surface stained, plastic embedded ground sections. Long-term stable occlusion was observed in all three models with the use of hydrogel-coated coils. However, platinum coils were as effective only in the canine sidewall model. With the use of hydrogel-coated coils, a two-fold increase in the volumetric filling of the aneurysm sac resulted in improved outcomes.

Graphical abstract: Hydrogel-coated and platinum coils for intracranial aneurysm embolization compared in three experimental models using computerized angiographic and histologic morphometry

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Publication details

The article was received on 11 May 2007, accepted on 20 Aug 2007 and first published on 31 Aug 2007


Article type: Application
DOI: 10.1039/B707177A
J. Mater. Chem., 2007,17, 3965-3973

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    Hydrogel-coated and platinum coils for intracranial aneurysm embolization compared in three experimental models using computerized angiographic and histologic morphometry

    G. M. Cruise, J. C. Shum and H. Plenk, J. Mater. Chem., 2007, 17, 3965
    DOI: 10.1039/B707177A

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