Jump to main content
Jump to site search

Issue 16, 2007
Previous Article Next Article

Mesoporous maghemite–organosilica microspheres: a promising route towards multifunctional platforms for smart diagnosis and therapy

Author affiliations

Abstract

We report facile fabrication of advanced hybrid silica–spinel iron oxide (maghemite) composite microspheres built with both superparamagnetic nanoparticles for MR imaging, hyperthermia, and a hybrid mesoporous matrix enabling the transport of bioactive molecules for in vivo biomedical applications. Elaboration of such multifunctional platforms is performed by spray drying a sol of tunable composition that allows one to control the size and amount of magnetic particles embedded in the matrix, without aggregation, and to adjust the size and the surface chemical properties of the porous silica cavities. The resulting nanocomposites (γ-Fe2O3 8 nm particles in silica matrices from TEOS templated by CTAB or P123, without or with functionalisation with –Ph, –SH or –NH2) were characterised by chemical analysis, XRD, TEM, BET, FTIR and magnetisation measurements. Tests of the materials both as MRI T2-contrast agents and as heating sources of hyperthermia are presented in support of potential applications in diagnosis and therapy.

Graphical abstract: Mesoporous maghemite–organosilica microspheres: a promising route towards multifunctional platforms for smart diagnosis and therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Nov 2006, accepted on 25 Jan 2007 and first published on 16 Feb 2007


Article type: Paper
DOI: 10.1039/B615951F
J. Mater. Chem., 2007,17, 1563-1569

  •   Request permissions

    Mesoporous maghemite–organosilica microspheres: a promising route towards multifunctional platforms for smart diagnosis and therapy

    B. Julián-López, C. Boissière, C. Chanéac, D. Grosso, S. Vasseur, S. Miraux, E. Duguet and C. Sanchez, J. Mater. Chem., 2007, 17, 1563
    DOI: 10.1039/B615951F

Search articles by author

Spotlight

Advertisements