Issue 11, 2007

Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

Abstract

The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium (choline derivatives) and alkyl-triethylammonium salts towards HeLa cells has been studied. The relative toxicities have been determined in the presence and absence of foetal bovine serum using an MTT assay after 24 and 48 h, and attempts to determine possible sources of the observed toxicity investigated using microscopy and by measuring the intracellular calcium concentration, presence of reactive oxygen species and mitochondrial membrane potential in cells exposed to 1-ethyl-3-methylimidazolium tetrafluoroborate.

Graphical abstract: Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

Supplementary files

Article information

Article type
Paper
Submitted
26 Mar 2007
Accepted
19 Jul 2007
First published
03 Aug 2007

Green Chem., 2007,9, 1191-1197

Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

X. Wang, C. A. Ohlin, Q. Lu, Z. Fei, J. Hu and P. J. Dyson, Green Chem., 2007, 9, 1191 DOI: 10.1039/B704503D

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