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Issue 9, 2007
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Copper(ii) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis

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Abstract

Two molecular structures of the copper(II) complex, Cu(H2TETA), have been determined by X-ray crystallography. The Jahn–Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(II) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn–Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(II) complexes formed. The single crystal X-ray structures of two copper(II) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.

Graphical abstract: Copper(ii) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis

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Supplementary files

Article information


Submitted
23 Oct 2006
Accepted
16 Jan 2007
First published
01 Feb 2007

This article is Open Access

Dalton Trans., 2007, 971-978
Article type
Paper

Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis

J. D. Silversides, C. C. Allan and S. J. Archibald, Dalton Trans., 2007, 971
DOI: 10.1039/B615329A

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