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Issue 13, 2007
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Ruthenium complexes can target determinants of tumour malignancy

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Abstract

Metastases are more decisive for tumour prognosis than primary lesions, because of their multiple locations, low accessibility to surgery and/or radiotherapy, and generally poor responsiveness to chemotherapy. The metastasis should therefore be the primary target for drug therapy. Among ruthenium complexes, NAMI-A is a leading compound that shows selective effects for solid tumour metastases related to a mechanism of action involving the inhibition of the processes of tumour invasiveness. NAMI-A opens an avenue to new perspectives in cancer chemotherapy. This includes novel compounds directed at targets selectively expressed by tumour metastases, thus reducing the typical side effects of the current metal-based drugs that are active via their unselective DNA interaction.

Graphical abstract: Ruthenium complexes can target determinants of tumour malignancy

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Article information


Submitted
05 Dec 2006
Accepted
12 Feb 2007
First published
28 Feb 2007

Dalton Trans., 2007, 1267-1272
Article type
Perspective

Ruthenium complexes can target determinants of tumour malignancy

A. Bergamo and G. Sava, Dalton Trans., 2007, 1267
DOI: 10.1039/B617769G

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