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Issue 6, 2007
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Metals in membranes

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Abstract

In this critical review we discuss recent advances in understanding the modes of interaction of metal ions with membraneproteins, including channels, pumps, transporters, ATP-binding cassetteproteins, G-protein coupled receptors, kinases and respiratory enzymes. Such knowledge provides a basis for elucidating the mechanism of action of some classes of metallodrugs, and a stimulus for the further exploration of the coordination chemistry of metal ions in membranes. Such research offers promise for the discovery of new drugs with unusual modes of action. The article will be of interest to bioinorganic chemists, chemical biologists, biochemists, pharmacologists and medicinal chemists. (247 references)

Graphical abstract: Metals in membranes

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Publication details

The article was received on 21 Nov 2006 and first published on 10 Apr 2007


Article type: Critical Review
DOI: 10.1039/B617040B
Chem. Soc. Rev., 2007,36, 968-992

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    Metals in membranes

    X. Liang, D. J. Campopiano and P. J. Sadler, Chem. Soc. Rev., 2007, 36, 968
    DOI: 10.1039/B617040B

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