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Issue 47, 2007
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Carboranyl thymidine analogues for neutron capture therapy

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Abstract

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

Graphical abstract: Carboranyl thymidine analogues for neutron capture therapy

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Article information


Submitted
14 May 2007
Accepted
17 Jul 2007
First published
15 Aug 2007

Chem. Commun., 2007, 4978-4991
Article type
Feature Article

Carboranyl thymidine analogues for neutron capture therapy

W. Tjarks, R. Tiwari, Y. Byun, S. Narayanasamy and Rolf. F. Barth, Chem. Commun., 2007, 4978
DOI: 10.1039/B707257K

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