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Issue 35, 2007
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Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles

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Abstract

The transition metal-catalyzed addition of the X–H bond of a carbon, nitrogen or oxygen nucleophile across the C[double bond, length as m-dash]C bond of an unactivated alkene (hydrofunctionalization) represents an attractive, atom-economical approach to the synthesis of carbocyclic and heterocyclic molecules and for the elaboration of ethylene and 1-alkenes. We have developed a family of Pt(II)-catalyzed protocols for the inter- and intramolecular hydrofunctionalization of unactivated alkenes with a range of H–X nucleophiles including β-diketones, indoles, amines, carboxamides and alcohols. These transformations display good functional group compatibility, low moisture sensitivity, and often good generality.

Graphical abstract: Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles

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Article information


Submitted
30 Oct 2006
Accepted
20 Mar 2007
First published
13 Apr 2007

Chem. Commun., 2007, 3607-3618
Article type
Feature Article

Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles

C. Liu, C. F. Bender, X. Han and R. A. Widenhoefer, Chem. Commun., 2007, 3607
DOI: 10.1039/B615698C

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