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Issue 1, 2007

Chemistry and biology of resorcylic acid lactones

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Abstract

While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitorshave stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

Graphical abstract: Chemistry and biology of resorcylic acid lactones

Article information


Submitted
19 Jul 2006
Accepted
18 Aug 2006
First published
25 Sep 2006

Chem. Commun., 2007, 22-36
Article type
Feature Article

Chemistry and biology of resorcylic acid lactones

N. Winssinger and S. Barluenga, Chem. Commun., 2007, 22 DOI: 10.1039/B610344H

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