Issue 18, 2007

Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A

Abstract

The optimisation of a synthetic strategy towards the ABC segment of the cytotoxic macrolide spirastrellolide A is reported, together with its application to the synthesis of two diastereomeric C1–C22 fragments for stereochemical correlation purposes with a putative spirastrellolide degradation product.

Graphical abstract: Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A

Supplementary files

Article information

Article type
Communication
Submitted
18 Jan 2007
Accepted
29 Jan 2007
First published
14 Feb 2007

Chem. Commun., 2007, 1852-1854

Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A

I. Paterson, E. A. Anderson, S. M. Dalby, J. Genovino, J. H. Lim and C. Moessner, Chem. Commun., 2007, 1852 DOI: 10.1039/B700827A

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