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Issue 1, 2006
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Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging†

Ali Hayek,a   Frédéric Bolze,a   Jean-François Nicoud,*a   Patrice L. Baldeckb  and  Yves Mélyc  
Author affiliations

* Corresponding authors

a Groupe des Matériaux Organiques, Institut de Physique et Chimie des Matériaux de Strasbourg, CNRS (UMR 7504), 23 rue du Loess, Strasbourg, France
E-mail: nicoud@ipcms.u-strasbg.fr
Fax: 33 (0)3 88 10 72 46
Tel: 33 (0)3.88.10.71.55

b Laboratoire de Spectrométrie Physique, Université Joseph Fourier, CNRS (UMR 5588), BP 87, Saint Martin d'Hères, France
E-mail: baldeck@spectro.ujf-grenoble.fr
Fax: 33 (0)4 76 63 54 95
Tel: 33 (0)4 76 51 47 82

c Pharmacologie et Physico-chimie des Interactions Cellulaires et Moléculaires, CNRS (UMR 7034), Faculté de Pharmacie, 74, route du Rhin-BP 60024-67401 Illkirch-Graffenstaden, France
E-mail: yves.mely@pharma.u-strasbg.fr
Fax: 33(0)3 90 24 43 13
Tel: 33 (0)3 90 24 42 63

Abstract

We report here the synthesis and characterization of a new type of non-ionic blue fluorescent water-soluble chromophores specifically designed for two-photon absorption microscopy. The water solubility is induced by introduction of short oligo(ethylene glycol) monomethyl ether moieties. This work has led to low molecular weight dyes with efficient two-photon absorption cross sections and high fluorescence quantum yield in organic solvents as well as in aqueous solutions.

Graphical abstract: Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging

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Article information

Submitted
11 Jul 2005
Accepted
07 Oct 2005
First published
11 Nov 2005
Photochem. Photobiol. Sci., 2006,5, 102-106
Article type
Paper
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Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging

A. Hayek, F. Bolze, J. Nicoud, P. L. Baldeck and Y. Mély, Photochem. Photobiol. Sci., 2006, 5, 102
DOI: 10.1039/B509843B

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