Issue 19, 2006
From the journal:

Organic & Biomolecular Chemistry

Chemical synthesis of picornaviral protein primers of RNA replication

Nicole M. A. J. Kriek,a   Nico J. Meeuwenoord,a   Hans van den Elst,a   Hans A. Heus,b   Gijsbert A. van der Marel*a  and  Dmitri V. Filippov*a  

* Corresponding authors

a Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, RA Leiden, The Netherlands
E-mail: filippov@chem.leidenuniv.nl, marel_g@chem.leidenuniv.nl
Fax: +31–71-5274307
Tel: +31–71-5274280

b Radboud University Nijmegen, Institute for Molecules and Materials, Laboratory of Biophysical Chemistry, Nijmegen, Toernooiveld 1, The Netherlands
E-mail: H.Heus@nmr.ru.nl

Abstract

Naturally occurring nucleopeptidic replication primers (VPg–pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg–pUpU of coxsackie virus was characterized by NMR spectroscopy.

Graphical abstract: Chemical synthesis of picornaviral protein primers of RNA replication

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Article information

DOI
https://doi.org/10.1039/B608544J
Article type
Paper
Submitted
15 Jun 2006
Accepted
10 Aug 2006
First published
30 Aug 2006

Org. Biomol. Chem., 2006,4, 3576-3586

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Chemical synthesis of picornaviral protein primers of RNA replication

N. M. A. J. Kriek, N. J. Meeuwenoord, H. van den Elst, H. A. Heus, G. A. van der Marel and D. V. Filippov, Org. Biomol. Chem., 2006, 4, 3576 DOI: 10.1039/B608544J

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