Issue 16, 2006
From the journal:

Organic & Biomolecular Chemistry

New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

Alexandra Fagerström,a   Mikael Nilsson,b   Ulf Berg*a  and  Roland Isaksson*b  

* Corresponding authors

a Organic Chemistry, Department of Chemistry, P.O. Box 124, Lund University, Lund, Sweden
E-mail: Ulf.Berg@organic.lu.se

b Department of Biomedical Sciences, University of Kalmar, Kalmar, Sweden
E-mail: Roland.Isaksson@hik.se

Abstract

Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

Graphical abstract: New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

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Article information

DOI
https://doi.org/10.1039/B605603B
Article type
Paper
Submitted
20 Apr 2006
Accepted
23 Jun 2006
First published
19 Jul 2006

Org. Biomol. Chem., 2006,4, 3067-3076

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New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

A. Fagerström, M. Nilsson, U. Berg and R. Isaksson, Org. Biomol. Chem., 2006, 4, 3067 DOI: 10.1039/B605603B

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