Issue 10, 2006
From the journal:

Organic & Biomolecular Chemistry

An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

Claire E. T. Mitchell,a   Stacey E. Brenner,a   Jorge García-Fortaneta  and  Steven V. Ley*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 (0) 1223 336442

Abstract

5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this transformation requires short reaction times, tolerates a broad substrate scope, and possibly proceeds via generation of an iminium species.

Graphical abstract: An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

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Article information

DOI
https://doi.org/10.1039/B601877G
Article type
Paper
Submitted
07 Feb 2006
Accepted
13 Mar 2006
First published
20 Apr 2006

Org. Biomol. Chem., 2006,4, 2039-2049

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An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones

C. E. T. Mitchell, S. E. Brenner, J. García-Fortanet and S. V. Ley, Org. Biomol. Chem., 2006, 4, 2039 DOI: 10.1039/B601877G

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