Issue 1, 2006
From the journal:

Organic & Biomolecular Chemistry

Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

Cheng-Sheng Jia,a   Ze Zhang,a   Shu-Jiang Tub  and  Guan-Wu Wang*a  

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China
E-mail: gwang@ustc.edu.cn
Fax: +86-551-360-7864

b Department of Chemistry and Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou Normal University, Xuzhou, Jiangsu, P. R. China

Abstract

A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedländer condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.

Graphical abstract: Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

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Article information

DOI
https://doi.org/10.1039/B513721G
Article type
Paper
Submitted
27 Sep 2005
Accepted
28 Oct 2005
First published
18 Nov 2005

Org. Biomol. Chem., 2006,4, 104-110

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Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

C. Jia, Z. Zhang, S. Tu and G. Wang, Org. Biomol. Chem., 2006, 4, 104 DOI: 10.1039/B513721G

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