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Issue 6, 2006
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Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics

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Abstract

Covering: 1949–2006

The 2-deoxystreptamine-containing aminoglycosides are an important class of clinically valuable antibiotics. A deep understanding of the biosynthesis of these natural products is required to enable efforts to rationally manipulate and engineer the biological production of novel aminoglycosides. This review discusses the development of our biosynthetic knowledge over the past half-century, with emphasis on the relatively recent contributions of molecular biology to the elucidation of these biosynthetic pathways.

Graphical abstract: Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics

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Publication details

The article was received on 07 Jul 2006 and first published on 25 Sep 2006


Article type: Review Article
DOI: 10.1039/B604709M
Nat. Prod. Rep., 2006,23, 864-874

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    Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics

    N. M. Llewellyn and J. B. Spencer, Nat. Prod. Rep., 2006, 23, 864
    DOI: 10.1039/B604709M

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