Kinetic preference for interaction of cisplatin with the G–C-rich wobble basepair region in both tRNAAla and MhAla

Pal Papsai; Jasmin Aldag; Tina Persson; Sofi K. C. Elmroth

doi:10.1039/B603833F

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Kinetic preference for interaction of cisplatin with the G–C-rich wobble basepair region in both tRNA^Ala and Mh^Ala†

Pal Papsai,^a Jasmin Aldag,^a Tina Persson^b and Sofi K. C. Elmroth*^a

Author affiliations

* Corresponding authors

^a Biochemistry, Chemical Center, Lund University, P. O. Box 124, Lund, Sweden
E-mail: sofi.elmroth@biochemistry.lu.se
Fax: +46 46 222 4534
Tel: +46 46 222 8194

^b Organic Chemistry, Chemical Center, Lund University, P. O. Box 124, Lund, Sweden
Fax: +46 46 222 8209
Tel: +46 46 222 8210

Abstract

The anticancer active complex cisplatin interacts preferentially with the common, G–C rich, wobble base pair region of both tRNA^Ala and Mh^Ala in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex.

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Supplementary files

Detailed experimental protocols. PDF (207K)

Article information

DOI: https://doi.org/10.1039/B603833F
Article type: Communication
Submitted: 15 Mar 2006
Accepted: 25 May 2006
First published: 09 Jun 2006

Download Citation

Dalton Trans., 2006, 3515-3517

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Kinetic preference for interaction of cisplatin with the G–C-rich wobble basepair region in both tRNA^Ala and Mh^Ala

P. Papsai, J. Aldag, T. Persson and S. K. C. Elmroth, Dalton Trans., 2006, 3515 DOI: 10.1039/B603833F

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Dalton Transactions