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Issue 6, 2006
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Design of targeting ligands in medicinal inorganic chemistry

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Abstract

This tutorial review will highlight recent advances in medicinal inorganic chemistry pertaining to the use of multifunctional ligands for enhanced effect. Ligands that adequately bind metal ions and also include specific targeting features are gaining in popularity due to their ability to enhance the efficacy of less complicated metal-based agents. Moving beyond the traditional view of ligands modifying reactivity, stabilizing specific oxidation states, and contributing to substitution inertness, we will discuss recent work involving metal complexes with multifunctional ligands that target specific tissues, membrane receptors, or endogenous molecules, including enzymes.

Graphical abstract: Design of targeting ligands in medicinal inorganic chemistry

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Publication details

The article was received on 31 Mar 2006 and first published on 20 Apr 2006


Article type: Tutorial Review
DOI: 10.1039/B514859F
Chem. Soc. Rev., 2006,35, 534-544

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    Design of targeting ligands in medicinal inorganic chemistry

    T. Storr, K. H. Thompson and C. Orvig, Chem. Soc. Rev., 2006, 35, 534
    DOI: 10.1039/B514859F

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