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Issue 46, 2006
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A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

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Abstract

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

Graphical abstract: A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

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Supplementary files

Article information


Submitted
24 Aug 2006
Accepted
19 Sep 2006
First published
03 Oct 2006

Chem. Commun., 2006, 4835-4837
Article type
Communication

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

I. R. Baxendale, S. V. Ley, C. D. Smith and G. K. Tranmer, Chem. Commun., 2006, 4835
DOI: 10.1039/B612197G

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