Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays

Wenhui Zhou; John W. Shultz; Nancy Murphy; Erika M. Hawkins; Laurent Bernad; Troy Good; Leonard Moothart; Susan Frackman; Dieter H. Klaubert; Robert F. Bulleit; Keith V. Wood

doi:10.1039/B610682J

Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays†

Wenhui Zhou,*^a John W. Shultz,*^b Nancy Murphy,^b Erika M. Hawkins,^b Laurent Bernad,^a Troy Good,^a Leonard Moothart,^a Susan Frackman,^b Dieter H. Klaubert,^a Robert F. Bulleit^b and Keith V. Wood^b

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* Corresponding authors

^a Promega Biosciences Inc, 277 Granada Drive, San Luis Obispo, CA 93401, USA
E-mail: wenhui.zhou@promega.com
Fax: 001 8055431531
Tel: 001 8055448524

^b Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711-5399, USA
E-mail: john.shultz@promega.com
Fax: 001 6082772601
Tel: 001 6082744330

Abstract

New highly sensitive latent bioluminescent luciferin substrates were designed and synthesized for monitoring mammalian glutathione S-transferase (GST) and Schistosoma japonicum enzyme activities.

Chemical Communications

Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays†

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Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays

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