Issue 41, 2006
From the journal:

Chemical Communications

Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

Manfred T. Reetz,*a   Jérôme J.-P. Peyralans,a   Andrea Maichele,a   Yu Fua  and  Matthias Maywalda  

* Corresponding authors

a Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany
E-mail: reetz@mpi-muelheim.mpg.de
Fax: +49 208 306 2985

Abstract

The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal–ligand centers anchored to proteins has been implemented experimentally for the first time.

Graphical abstract: Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

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Article information

DOI
https://doi.org/10.1039/B610461D
Article type
Communication
Submitted
21 Jul 2006
Accepted
16 Aug 2006
First published
05 Sep 2006

Chem. Commun., 2006, 4318-4320

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Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

M. T. Reetz, J. J.-P. Peyralans, A. Maichele, Y. Fu and M. Maywald, Chem. Commun., 2006, 4318 DOI: 10.1039/B610461D

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