Issue 36, 2006
From the journal:

Chemical Communications

Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors†

Ann-Marie Fanning,a   Sally E. Plusha  and  Thorfinnur Gunnlaugsson*a  

* Corresponding authors

a School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
E-mail: gunnlaut@tcd.ie
Fax: 00353 1671 2826
Tel: 00 353 1 608 3459

Abstract

The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.

Graphical abstract: Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors

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Article information

DOI
https://doi.org/10.1039/B609923H
Article type
Communication
Submitted
12 Jul 2006
Accepted
04 Aug 2006
First published
22 Aug 2006

Chem. Commun., 2006, 3791-3793

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Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors

A. Fanning, S. E. Plush and T. Gunnlaugsson, Chem. Commun., 2006, 3791 DOI: 10.1039/B609923H

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