Alkali-metal-catalyzed addition of primary and secondary phosphines to carbodiimides. A general and efficient route to substituted phosphaguanidines

Abstract

Organo alkali metal compounds such as ⁿBuLi and (Me₃Si)₂NK act as excellent catalyst precursors for the addition of phosphine P–H bonds to carbodiimides, offering a general and atom-economical route to substituted phosphaguanidines, with excellent tolerability to aromatic C–Br and C–Cl bonds.