Issue 33, 2006
From the journal:

Chemical Communications

7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes†

Takayuki Shibata,a   Niklaas J. Buurma,a   John A. Brazier,a   Peter Thompson,a   Ihtshamul Haqa  and  David M. Williams*a  

* Corresponding authors

a Centre for Chemical Biology, Department of Chemistry, Richard Roberts Building, University of Sheffield, Brook Hill, Sheffield, UK
E-mail: d.m.williams@sheffield.ac.uk
Fax: +44 (0)114 222 9346
Tel: +44 (0)114 222 9478

Abstract

Incorporation of a bicyclic cytosine analogue, 3-β-D-(2′-deoxyribofuranosyl)-7,8-dihydropyrido[2,3-d]pyrimidine, into synthetic DNA duplexes results in a greatly enhanced thermal stability (3–4 °C per modification) compared to the corresponding unmodified duplex.

Graphical abstract: 7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes

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Article information

DOI
https://doi.org/10.1039/B606058G
Article type
Communication
Submitted
28 Apr 2006
Accepted
19 Jun 2006
First published
11 Jul 2006

Chem. Commun., 2006, 3516-3518

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7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes

T. Shibata, N. J. Buurma, J. A. Brazier, P. Thompson, I. Haq and D. M. Williams, Chem. Commun., 2006, 3516 DOI: 10.1039/B606058G

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