Issue 34, 2006
From the journal:

Chemical Communications

First highly stereoselective synthesis of anti-α-trifluoromethyl-β-amino acid derivatives

Taichi Shimada,a   Masamitsu Yoshioka,a   Tsutomu Konnoa  and  Takashi Ishihara*a  

* Corresponding authors

a Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Japan
E-mail: ishihara@kit.ac.jp
Fax: +81 75-724-7580
Tel: +81 75-724-7504

Abstract

The Reformatsky-type reaction of 2-bromo-3,3,3-trifluoropropanoic imide with various types of imines, in the presence of ZnBr2 as a Lewis acid in THF at 0 °C for 3 h, gave the corresponding α-trifluoromethyl-β-amino acid derivatives in a highly anti-selective manner.

Graphical abstract: First highly stereoselective synthesis of anti-α-trifluoromethyl-β-amino acid derivatives

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Article information

DOI
https://doi.org/10.1039/B603882D
Article type
Communication
Submitted
17 Mar 2006
Accepted
30 May 2006
First published
26 Jul 2006

Chem. Commun., 2006, 3628-3630

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First highly stereoselective synthesis of anti-α-trifluoromethyl-β-amino acid derivatives

T. Shimada, M. Yoshioka, T. Konno and T. Ishihara, Chem. Commun., 2006, 3628 DOI: 10.1039/B603882D

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