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Issue 19, 2006
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Creating carbon–carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides

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Abstract

In this perspective, an overview of our experiences on the application of samarium diiodide in organic synthesis for the preparation of amino acid and peptide analogues is presented. Three different carbon–carbon bond forming reactions are discussed, including side chain introductions, γ-amino acid synthesis and acyl-like radical additions for the construction of C–C mimics of the peptidic bonds.

Graphical abstract: Creating carbon–carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides

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Publication details

The article was received on 06 Jun 2006, accepted on 16 Aug 2006 and first published on 01 Sep 2006


Article type: Perspective
DOI: 10.1039/B608028F
Org. Biomol. Chem., 2006,4, 3553-3564

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    Creating carbon–carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides

    J. Ebran, C. M. Jensen, S. A. Johannesen, J. Karaffa, K. B. Lindsay, R. Taaning and T. Skrydstrup, Org. Biomol. Chem., 2006, 4, 3553
    DOI: 10.1039/B608028F

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