Creating carbon–carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides

Abstract

In this perspective, an overview of our experiences on the application of samarium diiodide in organic synthesis for the preparation of amino acid and peptide analogues is presented. Three different carbon–carbon bond forming reactions are discussed, including side chain introductions, γ-amino acid synthesis and acyl-like radical additions for the construction of C–C mimics of the peptidic bonds.