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Issue 11, 2006
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Catalytic asymmetric fluorinations

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The appearance of structurally diverse fluorinating reagents displaying a large spectrum of reactivity has been critical to the development of the catalytic asymmetric fluorination processes known to date. In this article, we discuss how this area of research emerged and which strategies have allowed for the successful development of both nucleophilic and electrophilic catalytic enantioselective fluorinations. We also present the fundamental understanding of catalytic activity and enantioselectivity for the most efficient processes and highlight the first synthetic application with the preparation of a complex fluorinated target.

Graphical abstract: Catalytic asymmetric fluorinations

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Publication details

The article was received on 02 Mar 2006 and first published on 03 May 2006

Article type: Perspective
DOI: 10.1039/B603163C
Org. Biomol. Chem., 2006,4, 2065-2075

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    Catalytic asymmetric fluorinations

    C. Bobbio and V. Gouverneur, Org. Biomol. Chem., 2006, 4, 2065
    DOI: 10.1039/B603163C

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