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Issue 1, 2006
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Artificial ribonucleases

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Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists. During the past decade, mimics for RNA-cleaving enzymes, ribonucleases, or, more precisely, mimics of ribozymes that cleave RNA in sequence-selective rather than base-selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides (or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.

Graphical abstract: Artificial ribonucleases

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The article was received on 25 Jul 2005, accepted on 30 Sep 2005 and first published on 28 Oct 2005

Article type: Perspective
DOI: 10.1039/B509022A
Org. Biomol. Chem., 2006,4, 15-25

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    Artificial ribonucleases

    T. Niittymäki and H. Lönnberg, Org. Biomol. Chem., 2006, 4, 15
    DOI: 10.1039/B509022A

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