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Issue 12, 2006
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PDMS absorption of small molecules and consequences in microfluidic applications

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Abstract

Microfluidic devices made out of polydimethylsiloxane (PDMS) have many physical properties that are useful for cell culture applications, such as transparency and gas permeability. Another distinct characteristic of PDMS is its ability to absorb hydrophobic small molecules. Partitioning of molecules into PDMS can significantly change solution concentrations and could potentially alter experimental outcomes. Herein we discuss PDMS absorption and its potential impact on microfluidic experiments.

Graphical abstract: PDMS absorption of small molecules and consequences in microfluidic applications

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Article information


Submitted
23 Aug 2006
Accepted
18 Sep 2006
First published
04 Oct 2006

Lab Chip, 2006,6, 1484-1486
Article type
Focus

PDMS absorption of small molecules and consequences in microfluidic applications

M. W. Toepke and D. J. Beebe, Lab Chip, 2006, 6, 1484
DOI: 10.1039/B612140C

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