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Issue 12, 2006
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Overcoming interferences in inductively coupled plasma mass spectrometryvia gas-flow modulation

Part 1. Fourier transform methods

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Abstract

The first of two new methods for reducing oxide interferences in inductively coupled plasma mass spectrometry is described. This method utilizes careful manipulation of the central-channel gas flow to impart distinguishable frequency-specific behavior to analyte and oxide species. Subsequently, application of a Fourier transform (FT) permits contributions from the analyte and oxide superimposed at a given mass to be unraveled. Through application of this correction method, a greater than ten-fold error at m/z 156 caused by the interference of 140Ce16O+ on 156Gd+ has been effectively eliminated. This correction method is well suited for overcoming multiple analyteoxide interferences (most notably where monoisotopic elements have been compromised) in a simultaneous manner. Although a time-of-flight mass analyzer was utilized here, this correction method is well suited also for implementation with scan-based systems (e.g. quadrupoles and sector-field mass spectrometers).

Graphical abstract: Overcoming interferences in inductively coupled plasma mass spectrometry via gas-flow modulation Part 1. Fourier transform methods

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Article information


Submitted
23 Jun 2006
Accepted
10 Aug 2006
First published
13 Sep 2006

J. Anal. At. Spectrom., 2006,21, 1367-1376
Article type
Paper

Overcoming interferences in inductively coupled plasma mass spectrometry via gas-flow modulation

W. C. Wetzel and G. M. Hieftje, J. Anal. At. Spectrom., 2006, 21, 1367
DOI: 10.1039/B608917H

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