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Issue 6, 2006
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Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

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Abstract

Gadolinium(III) complexes are often used in clinical MRI to increase contrast by selectively relaxing the water molecules near the complex. There is a desire to improve the sensitivity (relaxivity) of these contrast agents in order to detect molecular targets. This tutorial review describes the molecular factors that contribute to relaxivity and illustrates with recent examples how these can be optimized. It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging.

Graphical abstract: Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

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Article information


Submitted
10 Apr 2006
First published
03 May 2006

Chem. Soc. Rev., 2006,35, 512-523
Article type
Tutorial Review

Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

P. Caravan, Chem. Soc. Rev., 2006, 35, 512
DOI: 10.1039/B510982P

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