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Issue 44, 2006
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Excited state dynamics and fragmentation channels of the protonated dipeptide H2N-Leu-Trp-COOH

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Abstract

The excited state dynamics of the isolated and protonated peptide H2N-Leu-Trp-COOH are analyzed by fs pump–probe spectroscopy. The peptides are brought into the gas phase by electrospray ionization, and fs pump–probe excitation is detected by fragment ion formation. The pump laser addressed the excited ππ* state of the indole chromophore of the amino acid tryptophan. The subsequent excited state dynamics agreed with a biexponential decay with time constants of 500 fs and 10 ps. This is considerably shorter than the lifetime of neutral tryptophan in solution and in proteins, but similar to isolated, protonated tryptophan. Several models are discussed to explain the experimental results but the detailed quenching mechanism remains unresolved.

Graphical abstract: Excited state dynamics and fragmentation channels of the protonated dipeptide H2N-Leu-Trp-COOH

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Article information


Submitted
07 Jul 2006
Accepted
15 Sep 2006
First published
27 Sep 2006

Phys. Chem. Chem. Phys., 2006,8, 5247-5254
Article type
Paper

Excited state dynamics and fragmentation channels of the protonated dipeptide H2N-Leu-Trp-COOH

D. Nolting, T. Schultz, I. V. Hertel and R. Weinkauf, Phys. Chem. Chem. Phys., 2006, 8, 5247
DOI: 10.1039/B609726J

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