Issue 45, 2006
From the journal:

Chemical Communications

Tetramethylpyridiniumporphyrazines—a new class of G-quadruplex inducing and stabilising ligands†

Diana P. N. Gonçalves,a   Raphaël Rodriguez,a   Shankar Balasubramaniana  and  Jeremy K. M. Sanders*a  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: jkms@cam.ac.uk
Fax: +44 (0) 1223 336017
Tel: +44 (0) 1223 336411

Abstract

3,4-Tetramethylpyridiniumporphyrazines bind strongly and selectively to human telomeric G-quadruplex DNA, inducing the formation of an antiparallel quadruplex in a process that mimics molecular chaperones.

Graphical abstract: Tetramethylpyridiniumporphyrazines—a new class of G-quadruplex inducing and stabilising ligands

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Article information

DOI
https://doi.org/10.1039/B611731G
Article type
Communication
Submitted
15 Aug 2006
Accepted
12 Sep 2006
First published
27 Sep 2006

Chem. Commun., 2006, 4685-4687

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Tetramethylpyridiniumporphyrazines—a new class of G-quadruplex inducing and stabilising ligands

D. P. N. Gonçalves, R. Rodriguez, S. Balasubramanian and J. K. M. Sanders, Chem. Commun., 2006, 4685 DOI: 10.1039/B611731G

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