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Issue 2, 2006
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Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum

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Abstract

A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I β-turn, which is stabilized by hydrogen bonding between the CO of Asn2 and the NH of Ala5 as well as between the O(δ) of Asn2 and the NH of Asn4.

Graphical abstract: Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum

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Publication details

The article was received on 29 Jul 2005, accepted on 18 Oct 2005 and first published on 21 Nov 2005


Article type: Communication
DOI: 10.1039/B510812H
Chem. Commun., 2006, 174-176

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    Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum

    A. Ghasparian, K. Moehle, A. Linden and J. A. Robinson, Chem. Commun., 2006, 174
    DOI: 10.1039/B510812H

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