Issue 2, 2006
From the journal:

Chemical Communications

Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum†

Arin Ghasparian,a   Kerstin Moehle,a   Anthony Lindena  and  John A. Robinson*a  

* Corresponding authors

a Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
E-mail: robinson@oci.unizh.ch

Abstract

A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I β-turn, which is stabilized by hydrogen bonding between the CO of Asn2 and the NH of Ala5 as well as between the O(δ) of Asn2 and the NH of Asn4.

Graphical abstract: Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum

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Article information

DOI
https://doi.org/10.1039/B510812H
Article type
Communication
Submitted
29 Jul 2005
Accepted
18 Oct 2005
First published
21 Nov 2005

Chem. Commun., 2006, 174-176

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Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum

A. Ghasparian, K. Moehle, A. Linden and J. A. Robinson, Chem. Commun., 2006, 174 DOI: 10.1039/B510812H

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