Issue 22, 2005
From the journal:

Organic & Biomolecular Chemistry

Mild and efficient method for the cleavage of benzylidene acetals by using erbium (iii) triflate

Antonio Procopio,*a   Renato Dalpozzo,b   Antonio De Nino,b   Loredana Maiuolo,b   Monica Nardib  and  Giovanni Romeoc  

* Corresponding authors

a Dipartimento di Scienze Farmaco-Biologiche, Università della Magna Graecia, Complesso Ninì Barbieri, 88021 Roccelletta di Borgia (Cz), Italy
E-mail: procopio@unicz.it
Fax: +39-0961-391270
Tel: +39-0961-391095

b Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende (Cs), Italy

c Dipartimento Farmaco-Chimico Università di Messina, Viale SS. Annunziata, 98168 Messina, Italy

Abstract

Er(OTf)3 is proposed as new efficient Lewis acid catalyst in a mild deprotection protocol of benzylidene derivatives. In a modified procedure, where acetic anhydride is used as the reaction solvent, the simultaneous cleavage of the benzylidene acetal and the peracetylation of the substrates is obtained in quantitative yields and very short reaction times.

Graphical abstract: Mild and efficient method for the cleavage of benzylidene acetals by using erbium (iii) triflate

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Article information

DOI
https://doi.org/10.1039/B511314H
Article type
Paper
Submitted
09 Aug 2005
Accepted
19 Sep 2005
First published
17 Oct 2005

Org. Biomol. Chem., 2005,3, 4129-4133

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Mild and efficient method for the cleavage of benzylidene acetals by using erbium (III) triflate

A. Procopio, R. Dalpozzo, A. De Nino, L. Maiuolo, M. Nardi and G. Romeo, Org. Biomol. Chem., 2005, 3, 4129 DOI: 10.1039/B511314H

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