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Issue 15, 2005
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Evaluation of a new linker system cleaved using samarium(ii) iodide. Application in the solid phase synthesis of carbonyl compounds

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Abstract

A new linker design for solid phase synthesis has been developed that is cleaved under mild, neutral conditions using samarium(II) iodide. The feasibility of the linker approach has been illustrated in the solid phase synthesis of ketones and amides using an oxygen linker. Insights into the mechanism of the samarium(II) iodide cleavage reaction are described and the potential of a sequential cleavage carbon–carbon bond forming process is assessed.

Graphical abstract: Evaluation of a new linker system cleaved using samarium(ii) iodide. Application in the solid phase synthesis of carbonyl compounds

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Article information


Submitted
05 May 2005
Accepted
01 Jun 2005
First published
24 Jun 2005

Org. Biomol. Chem., 2005,3, 2805-2816
Article type
Paper

Evaluation of a new linker system cleaved using samarium(II) iodide. Application in the solid phase synthesis of carbonyl compounds

F. McKerlie, I. M. Rudkin, G. Wynne and D. J. Procter, Org. Biomol. Chem., 2005, 3, 2805
DOI: 10.1039/B506294B

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