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Issue 15, 2005
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Evaluation of a new linker system cleaved using samarium(II) iodide. Application in the solid phase synthesis of carbonyl compounds

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Abstract

A new linker design for solid phase synthesis has been developed that is cleaved under mild, neutral conditions using samarium(II) iodide. The feasibility of the linker approach has been illustrated in the solid phase synthesis of ketones and amides using an oxygen linker. Insights into the mechanism of the samarium(II) iodide cleavage reaction are described and the potential of a sequential cleavage carbon–carbon bond forming process is assessed.

Graphical abstract: Evaluation of a new linker system cleaved using samarium(ii) iodide. Application in the solid phase synthesis of carbonyl compounds

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Publication details

The article was received on 05 May 2005, accepted on 01 Jun 2005 and first published on 24 Jun 2005


Article type: Paper
DOI: 10.1039/B506294B
Citation: Org. Biomol. Chem., 2005,3, 2805-2816
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    Evaluation of a new linker system cleaved using samarium(II) iodide. Application in the solid phase synthesis of carbonyl compounds

    F. McKerlie, I. M. Rudkin, G. Wynne and D. J. Procter, Org. Biomol. Chem., 2005, 3, 2805
    DOI: 10.1039/B506294B

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