In contrast to the histone-modifying action of other complexes of the type CpMLnR, the compound obtained by linking the phenyl rings of two CpW(CO)3Ph moieties to the DNA-binding agent spermine selectively cleaves DNA in DNA–histone assemblies.
![Graphical abstract: Selective targeting of DNA for cleavage within DNA–histone assemblies by a spermine–[CpW(CO)3Ph]2 conjugate](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=B504248H&imageInfo.ImageIdentifier.Year=2005)
T. A. Shell and D. L. Mohler, Org. Biomol. Chem., 2005, 3, 3091 DOI: 10.1039/B504248H
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