Issue 9, 2005
From the journal:

Organic & Biomolecular Chemistry

A new method for the synthesis of acyltitanium complexes and their application to copper-mediated acylmetallation of carbon–carbon multiple bonds in aqueous media

Zhenfu Han,a   Takuma Fujioka,a   Shin-ichi Usugi,a   Hideki Yorimitsu,a   Hiroshi Shinokuboa  and  Koichiro Oshima*a  

* Corresponding authors

a Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto, Japan
E-mail: oshima@orgrxn.mbox.media.kyoto-u.ac.jp
Fax: 81 75 383 2438
Tel: 81 75 383 2437

Abstract

Treatment of α,β-unsaturated carbonyl compounds or methyl propargyl ether with acylchlorobis(cyclopentadienyl)titanium in the presence of triethylamine and a copper salt in aqueous THF resulted in acylation of the carbon–carbon multiple bond, yielding the corresponding 1,4-diketones in good yields.

Graphical abstract: A new method for the synthesis of acyltitanium complexes and their application to copper-mediated acylmetallation of carbon–carbon multiple bonds in aqueous media

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Article information

DOI
https://doi.org/10.1039/B503117F
Article type
Communication
Submitted
02 Mar 2005
Accepted
31 Mar 2005
First published
12 Apr 2005

Org. Biomol. Chem., 2005,3, 1622-1623

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A new method for the synthesis of acyltitanium complexes and their application to copper-mediated acylmetallation of carbon–carbon multiple bonds in aqueous media

Z. Han, T. Fujioka, S. Usugi, H. Yorimitsu, H. Shinokubo and K. Oshima, Org. Biomol. Chem., 2005, 3, 1622 DOI: 10.1039/B503117F

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