Issue 4, 2005

Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

Abstract

“Exchange protein directly activated by cAMP” (Epac) is a newly discovered cAMP receptor that mediates the intracellular cAMP actions in addition to the classic cAMP-dependent protein kinase system. In this study, we show that Epac interacts directly with tubulin, co-purifies with cellular microtubules, and co-localizes with the mitotic spindle assembly. Association with microtubules suppresses Epac-mediated Rap1 activation, while the binding of Epac promotes microtubule formation. These results demonstrate that Epac plays an important role in connecting the microtubule cytoskeleton network and intracellular cAMP-signalling.

Graphical abstract: Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

Supplementary files

Article information

Article type
Paper
Submitted
08 Aug 2005
Accepted
09 Sep 2005
First published
26 Sep 2005

Mol. BioSyst., 2005,1, 325-331

Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

F. C. Mei and X. Cheng, Mol. BioSyst., 2005, 1, 325 DOI: 10.1039/B511267B

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