Issue 10, 2005
From the journal:

Green Chemistry

Hydrogenation in supercritical 1,1,1,2 tetrafluoroethane (HFC 134a)

Andrew P. Abbott,a   Wayne Eltringham,a   Eric G. Hope*a  and  Mazin Nicolab  

* Corresponding authors

a Chemistry Department, University of Leicester, Leicester, UK
E-mail: egh1@le.ac.uk
Fax: +44 116 252 3789

b Advanced Phytonics Ltd, Olway Works, Healey Road, Ossett, West Yorkshire, UK

Abstract

Conventional, unmodified, transition metal catalysts, substrates and reagents have sufficient solubility in sc HFC134a for organic synthesis. Reactivities (100% conversion in 2 h) and enantioselectivities (ca. 90%), comparable to those achievable in conventional organic solvents, are obtained in the asymmetric hydrogenation of a series of substrates in this alternative reaction medium using a rhodium(I)/MonoPhos catalyst.

Graphical abstract: Hydrogenation in supercritical 1,1,1,2 tetrafluoroethane (HFC 134a)

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Article information

DOI
https://doi.org/10.1039/B507554H
Article type
Paper
Submitted
27 May 2005
Accepted
11 Aug 2005
First published
02 Sep 2005

Green Chem., 2005,7, 721-725

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Hydrogenation in supercritical 1,1,1,2 tetrafluoroethane (HFC 134a)

A. P. Abbott, W. Eltringham, E. G. Hope and M. Nicola, Green Chem., 2005, 7, 721 DOI: 10.1039/B507554H

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