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Issue 8, 2005
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Ionic liquids as additives in the pig liver esterase (PLE) catalysed synthesis of chiral disubstituted malonates

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Abstract

This report describes the first application of hydroxylated and epoxylated ionic liquids as additives in the enantioselective hydrolysis of prochiral diester malonates using pig liver esterase (PLE) as catalyst. Less than 1% of a hydrophilic functionalised ionic liquid, used in combination with 10% isopropanol/water is sufficient to enhance the activity of the enzyme by a factor of up to 4 and also to increase the enantioselectivity of the reaction. Immobilisation of the PLE on Eupergit® C enabled successful recycling of the enzyme system.

Graphical abstract: Ionic liquids as additives in the pig liver esterase (PLE) catalysed synthesis of chiral disubstituted malonates

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Publication details

The article was received on 01 Mar 2005, accepted on 04 May 2005 and first published on 25 May 2005


Article type: Paper
DOI: 10.1039/B503010B
Green Chem., 2005,7, 602-605

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    Ionic liquids as additives in the pig liver esterase (PLE) catalysed synthesis of chiral disubstituted malonates

    S. Wallert, K. Drauz, I. Grayson, H. Gröger, P. Dominguez de Maria and C. Bolm, Green Chem., 2005, 7, 602
    DOI: 10.1039/B503010B

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