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Issue 15, 2005
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The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules

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Abstract

The boundary between the physical and biological sciences has been eroded in recent years with new physical methods applied to biology and biological molecules being used for new physical purposes. We have pioneered the application of a form of scanning probe microscopy based on a scanned nanopipette, originally developed by Hansma and co-workers, for reliable non-contact imaging over the surface of a live cell. We have found that the nanopipette can also be used for controlled local voltage-driven application of reagents or biomolecules and this can be used for controlled deposition and the local delivery of probes for mapping of specific species. In this article we review this progress, focussing on the physical principles and new phenomena that we have observed, and then outline the future applications that are now possible.

Graphical abstract: The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules

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Publication details

The article was received on 12 May 2005, accepted on 16 Jun 2005 and first published on 05 Jul 2005


Article type: Invited Article
DOI: 10.1039/B506743J
Citation: Phys. Chem. Chem. Phys., 2005,7, 2859-2866
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    The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules

    L. Ying, A. Bruckbauer, D. Zhou, J. Gorelik, A. Shevchuk, M. Lab, Y. Korchev and D. Klenerman, Phys. Chem. Chem. Phys., 2005, 7, 2859
    DOI: 10.1039/B506743J

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