Inactivation of human angiotensin converting enzyme by copper peptide complexes containing ATCUN motifs†
Abstract
The copper complex [KGHK-Cu]+ demonstrates catalytic inactivation of human angiotensin converting enzyme at sub-saturating concentrations, under oxidative conditions, with an observed rate constant k ∼ 2.9 ± 0.5 × 10−2 min−1.