Issue 29, 2005
From the journal:

Chemical Communications

Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

Olesya D. Fedoryak,a   Jai-Yoon Sul,b   Philip G. Haydonb  and  Graham C. R. Ellis-Davies*a  

* Corresponding authors

a Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
E-mail: ged@drexel.edu
Fax: +1 215 762 2299
Tel: +1 215 762 8794

b Department of Neuroscience, University of Pennsylvania Medical Center, Philadelphia, USA

Abstract

We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca2+ concentration in astrocytes.

Graphical abstract: Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

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Article information

DOI
https://doi.org/10.1039/B504922A
Article type
Communication
Submitted
07 Apr 2005
Accepted
17 May 2005
First published
13 Jun 2005

Chem. Commun., 2005, 3664-3666

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Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

O. D. Fedoryak, J. Sul, P. G. Haydon and G. C. R. Ellis-Davies, Chem. Commun., 2005, 3664 DOI: 10.1039/B504922A

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