Issue 28, 2005
From the journal:

Chemical Communications

Catalytic chemoselective addition of acetonitrile to enolizable aldehydes with cationic Ru complex/DBU combination†

Naoya Kumagai,a   Shigeki Matsunagaa  and  Masakatsu Shibasaki*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: mshibasa@mol.f.u-tokyo.ac.jp
Fax: +81-3-5684-5206
Tel: +81-3-5841-4830

Abstract

The cooperative catalysis of CpRu(PPh3)2(CH3CN)PF6 (1b) and DBU enables chemoselective nucleophilic activation of acetonitrile in the presence of base-sensitive aldehydes 2 to afford corresponding β-hydroxynitriles 3 in good yield.

Graphical abstract: Catalytic chemoselective addition of acetonitrile to enolizable aldehydes with cationic Ru complex/DBU combination

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Article information

DOI
https://doi.org/10.1039/B504519C
Article type
Communication
Submitted
31 Mar 2005
Accepted
09 May 2005
First published
09 Jun 2005

Chem. Commun., 2005, 3600-3602

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Catalytic chemoselective addition of acetonitrile to enolizable aldehydes with cationic Ru complex/DBU combination

N. Kumagai, S. Matsunaga and M. Shibasaki, Chem. Commun., 2005, 3600 DOI: 10.1039/B504519C

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